THURSDAY, 02 JUNE 2016 / PUBLISHED IN BLOG

Introduction to Stem Cell Myths and Facts

The term stem cell research gleans different reactions from people, both in the medical community and the wider public. Still an emerging science, stem cell research is shrouded by many myths and misconceptions. Here, we take on some of the most predominant myths to discuss the misconceptions and clarify the facts regarding this fast-growing branch of medicine.

Myth #1: Stem Cells Only Come from Embryos

FACT: False. Stem Cells Exist in All Bodies, from Embryos to Adults

Embryonic stem cells come from the early embryo and have the potential to produce all the specialized cells of the body. Because of this, they hold great promise for studying and potentially treating disease and injuries. Tissue or “adult” stem cells are found in the body throughout our lives. These cells maintain and repair many tissues in the body. Examples of these cells include blood stem cells, muscle stem cells, bone marrow stem cells, adipose tissue (fat) stem cells, and skin stem cells. Some of these adult stem cells are used in established medical and aesthetic treatments.

Myth #2: Induced Pluripotent Stem Cells (iPSCs) Eliminate the Need for Embryonic Cells

FACT: False. Research is Needed on All Types of Cells

It is not clear which cells will be most useful for which types of application. For the foreseeable future, side-by-side research on both embryonic and induced pluripotent stem cells is needed. Global Stem Cell Group’s research and treatment products use no embryonic stem cells.

Myth #3: Stem Cell Research Leads to Cloning Humans

FACT: False. Most Countries Prohibit Human Cloning

In most countries, even attempting to clone a human being is illegal. Some countries do allow something called “therapeutic cloning” for the purposes of studying a disease. In this procedure, scientists isolate embryonic stem cells from a cloned blastocyst (early stage embryo) but do not transfer the blastocyst into a womb. These stem cells are genetically matched to the donor organism for studying genetic disease. For example, stem cells could be generated using the nuclear transfer process described above, with the donor adult cell coming from a patient with diabetes or Alzheimer’s. The stem cells could be studied in the laboratory to help researchers understand what goes wrong in diseases like these. Therapeutic cloning also could be used to generate cells that are genetically identical to a patient’s. A patient transplanted with these cells would not suffer the problems associated with transplant rejection. To date, no human embryonic stem cell lines have been derived using therapeutic cloning.

Myth #4: Adult Stem Cells Are Only Found in Adults

FACT: False. Tissue Stem Cells Are Found in People of All Ages

There are three different types of stem cells: embryonic stem cells, induced pluripotent stem cells, and tissue-specific stem cells. It’s the tissue stem cells that are often called “adult” stem cells, but these “adult” stem cells are found in people of all ages.

Myth #5: Embryonic Stem Cell Research Is Banned in Europe

FACT: False. The Laws Vary Across the EU

EU member states have diverging regulatory positions on human embryonic stem cell research. For instance, in Germany, the use of embryos for research is heavily restricted under the Embryo Protection Act (Embryonenschutzgesetz) of 1991, which makes the derivation of embryonic stem cell lines a criminal offense. But in the UK, embryonic stem cell research is allowed, subject to licensing from the Human Fertilization and Embryology Authority (HFEA). Click here for country-by-country overviews for more details. Under the previous two European Framework programs (FP6 and F7), as well as the current program, Horizon 2020, human embryonic stem cell research can be funded, provided that the work is permitted by law in the country where it is to take place.

Myth #6: Stem Cell Research and Treatment Is Against the Law in the US

FACT: False. The FDA Regulates Stem Cell Products but They Are Not Illegal

The FDA does not regulate the practice of medicine, but rather drugs and medical devices and which of these can be marketed in the US. Under federal law, cultured (grown) stem cell products are considered a drug, but are not illegal. Adult stem cells, however, are not cultured—they exist in our bodies throughout our organs, blood, skin, teeth, fat, bone marrow, and other places. Adult stem cell therapy is currently used in the United States to treat conditions such as leukemia and other illnesses. Bone marrow consists of stem cells which have been transplanted for years in the US. Global Stem Cells Group offers stem cell treatments in countries where stem cell therapy is approved and regulated with no appreciable difference in safety record. Stem cell therapy technology is still under review by the FDA.

Myth #7: Bone Marrow Is the Best Source of Stem Cells

FACT: False. Bone Marrow Is Just One Source of Stem Cells

Bone marrow stem cells have been studied for decades and have been used to treat certain types of cancer. A great deal of research has been dedicated to understanding this source of stem cells and their potential. Bone marrow contains a number of different kinds of stem cells, one of which is mesenchymal stem cells. However, mesenchymal stem cells can also be found in adipose (fat) tissue at nearly 2000 times the frequency of bone marrow. Mesenchymal cells have the capability to become different types of tissues (blood vessels, muscle tissue, etc.) and are capable of communicating with other cells. In combination with other proteins, molecules, and regenerative cells found in adipose tissue, they also have the ability to reduce inflammation, regenerate damaged tissue, and grow new blood vessels, a process known as angiogenesis. Stem cells from adipose tissue are more accessible and abundant. They can be processed immediately and reintroduced into the body right away.

Myth #8: There Is a Risk of Rejection with Stem Cell Therapy

FACT: False. Autologous Stem Cells Eliminate the Risk of Rejection

When a patient’s stem cells are derived from his or her own body (such as fat tissue), there is no risk of rejection. In fact, studies thus far have indicated no safety issues with fat-derived autologous (from self) stem cells. Since these stem cells come from your own body, the risk of rejection is eliminated.